If either antibody is elevated, a confident IBS diagnosis can be made.Ī positive result on the test also indicates that the root cause of your IBS was an instance of food poisoning (gastroenteritis) that has led to a disruption in your gut microbiome. The test measures the levels of two antibodies, anti-CdtB and anti-vinculin, known to be elevated in the blood of the majority of patients experiencing IBS with diarrheal symptoms. Irritable bowel syndrome can be accurately ruled in with a simple, doctor-ordered antibody blood test. Alternatively, an antibody blood test can diagnose IBS more directly.

Traditionally, IBS was an exclusionary diagnosis, meaning other diseases - especially IBD - had to be ruled out in order to diagnose IBS. This disruption ultimately results in irritable bowel syndrome (IBS). Your gut microbiome is composed of billions of bacteria in your gut that, when balanced, keep your gut healthy. When these do not function properly, your gut microbiome is disrupted. The production of anti-vinculin is an autoimmune response and leads to gut nerve damage and improper functioning of the Interstitial Cells of Cajal (ICC) and Migrating Motor Complexes (MMC). Because CdtB and vinculin can look alike, your body can think it needs to fight back against vinculin, at which point it starts producing another antibody, anti-vinculin. CdtB looks in some ways like vinculin, a naturally occurring protein in your body that is critical in healthy gut function. When a toxin like CdtB enters your body, your immune system fights back with an antibody - in this case, your body creates anti-CdtB. The most common bacteria that cause food poisoning like Shigella, Campylobacter, Salmonella, and E.

The path from food poisoning to IBS has to do with a toxin called Cytolethal Distending Toxin B, or CdtB for short. IBS does not cause lasting harm to the bowels and does not lead to cancer however, it can severely impair you physically and emotionally.įood poisoning is the leading known cause of IBS, accounting for at least 60% of all diarrheal IBS cases. There are three types of IBS : diarrhea-predominant (IBS-D), constipation-predominant (IBS-C), and mixed-type ( IBS-M, where diarrhea and constipation both persist).

Nearly 40 million Americans suffer from IBS. If you are suffering from these symptoms, you're not alone. It causes persistent abdominal pain, cramping, gas, bloating, and change in stool - some combination of chronic diarrhea and constipation. Irritable bowel syndrome, or IBS, is a health issue found in your intestines.

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